While scientific research on cannabis has focused mostly on the multitude of compounds found in the budding part of the plant, a new study is rooting out therapeutic benefits from source with less visibility.
The aqueous extract derived from the roots of a pot plant — of which cannabissativine (CsAqEx) is the main component — presents anti-inflammatory activity in mice without noticeable negative side effects or toxicity, according to a study published in the Journal of Ethnopharmacology.
Specifically, researchers found CsAqEx is associated with the reduction of vascular extravasation — the leakage of blood or other fluids from a blood vessel or tube — and the migration of inflammatory cells, which help reduce inflammation at affected sites. No effects to the central nervous system were observed, and there was no spasmolytic effect — the contraction of soft tissues — in airways.
The results suggest that the anti-inflammatory effect of CsAqEx is related to the reduction of vascular extravasation and migration of inflammatory cells, without effects on the central nervous system. Moreover, there was no spasmolytic effect on airway smooth muscle and no toxicity was observed on mice.