Can you smoke weed on antibiotics?

Very useful article from Cannigma

Antibiotics are some of the most common medications, typically used to treat bacterial infections – so many wonder whether it is safe to continue using cannabis while taking a course of antibiotics. While research is extremely limited on the topic, there are no reports of problems mixing these two medications. Still some, but not all, antibiotics do list cannabis as a contraindication because of the potential to increase either the negative side effects of either the antibiotics or the cannabis. In addition, many compounds in cannabis have potent antibacterial effects on their own, and are being considered by researchers as a new antibiotic treatment against difficult to treat strains of bacteria.

Is it safe to mix cannabis and antibiotics?

One of the biggest questions about mixing cannabis and antibiotics is whether it is safe. Unfortunately, very little research has been done to see whether cannabis and antibiotics impact each other in ways that could be harmful. At the same time, despite an increase in overall cannabis use and potency in recent years, we have not seen case reports popping up about negative impacts from this common combination. However because many components of cannabis are processed via the liver metabolic pathways as some antibiotics, certain combinations of cannabinoids and antibiotics may increase side effects of either drug. Make sure to let your doctor know that you are using cannabis so they can prescribe an option that will not carry the risks of added side effects.

Will using cannabis reduce the effects of antibiotics?

While some worry that cannabis may reduce the effectiveness of antibiotics, we don’t have any research that suggests this is the case. In fact, compounds in cannabis, such as CBD, have antibacterial effects of their own and could be used to enhance the effectiveness of certain antibiotics against resistant strains of bacteria. As it turns out, many cannabinoids and terpenes have antibacterial effects. Fighting off bacterial threats is actually one of the functions that these cannabinoids and terpenes serve in protecting the plant’s overall health – so it’s an added bonus that might be able to help to protect us as well.  1 2 3

Which antibiotics are safe to use with cannabis?

There is always some risk when mixing medications that have not been intensively studied together. But at the same time, we don’t have much research suggesting antibiotics in general are unsafe with cannabis. While certain types of antibiotics won’t interact poorly with cannabis – some antibiotics do. Additionally the term cannabis isn’t descriptive enough, as CBD and THC interact with certain medications differently, so knowing the chemical profile of the cannabis product you’re using is important. Always double check with your doctor or pharmacist that an antibiotic is appropriate for use with a cannabis product.

Cannabis is generally okay to take with:

  • Amoxicillin
  • Amoxicillin/Clavulanate
  • Cephalexin
  • Cefdinir
  • Doxycycline

Cannabis may interact with:

  • Clindamycin
  • Erythromycin
  • Clarithromycin
  • Azithromycin
  • Sulfamethoxazole/Trimethoprim
  • Rifampin
  • Metronidazole

Note: these lists are not exhaustive.

Sometimes the concern with drug interactions is that cannabis can slow or hasten the clearance of the antibiotics, and CBD is generally of more concern than THC in this case. The other thing that can happen is that certain medications may reduce the metabolism of the cannabis itself, resulting in higher than expected blood levels of cannabinoids. This could lead to increased psychoactive side effects from cannabis, such as anxiety, dizziness, drowsiness, or paranoia.

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